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Integrated relational Enzyme database. IntEnz. Enzymes. Enzymes are proteins that catalyze chemical reactions. Very important as many processes in biological cells need enzymes.... As there are many enzymes in the world, a classification system was invented to help identify and name them.
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Integrated relational Enzyme databaseIntEnzIntEnzEnzymes
  • Enzymes are proteins that catalyze chemical reactions.
  • Very important as many processes in biological cells need enzymes....
  • As there are many enzymes in the world, a classification system was invented to help identify and name them...
  • IntEnzNC-IUBMB
  • In the 1950’s the increasing amounts of known enzymes were causing confusion. No official nomenclature system for enzymes.
  • The IUBMB created the International Commission on Enzymes in 1956 to deal with enzyme nomenclature
  • Later replaced with the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)
  • IntEnzEC Numbers
  • NC-IUBMB developed the Enzyme Classification number system (EC)
  • Classification system is based on the reactions the enzymes catalyzed
  • Classification:
  • Classes
  • Subclasses
  • Sub-subclasses
  • EC numbers (Enzyme Commission)
  • Example EC 1.1.1.1
  • IntEnzEC Classification - Classes
  • EC 1 – Oxidoreductases; catalyze oxidation/reduction reactions.
  • EC 2 – Transferases; transfer a functional group e.g. Methyl group.
  • EC 3 – Hydrolases; catalyse the hydrolysis of various bonds.
  • EC 4 – Lyases; cleave various bonds by means other than hydrolysis and oxidation
  • EC 5 – Isomerases; catalyse changes within one molecule.
  • EC 6 – Ligases; joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
  • IntEnzEC numbers lifecycleNewRejectedPrivateSuggestedDeletedProposedTransferredPublicAcceptedIntEnzIntEnz (www.ebi.ac.uk/intenz)IntEnzWhat's in IntEnzOfficial Enzyme nomenclature from NC-IUBMBData from ENZYME database (SIB)CofactorsExtra cross references: UniProtKB/Swiss-Prot, PrositeExtra cross references: CSA, GOEnzyme spotlightsTwo different views of the same data:IntEnzENZYMEIntEnzThe (official) enzyme nomenclatureClassification:ClassesSubclassesSub-subclassesEC numbers (Enzyme Commission)NomenclatureReactions (as plain text)CommentsCross references: BRENDA, EXPASY, KEGG, ERGO, PDB, CAS registryBibliographic referencesMaintained by NC-IUBMBIntEnzIntEnz EntryClassification systemAccepted NameReaction (Rhea)Cofactor (ChEBI)IntEnzIntEnz entry continuedUniProt LinksCitationsIntEnzSimple searchSearch by EC number:1.1.1.11.2.3.121.13.1.13
  • Search by cross-reference:
  • Q42884
  • GO:0047948
  • Search by enzyme name:
  • Oxalate oxidase
  • Agarase
  • 3/4 collagenase
  • Search by compound:
  • Caffeine
  • CoA
  • IntEnzSimple Search ExampleIntEnzAdvanced searchSearch by reaction participant:CoACoA-SHCoASHCoenzyme-A
  • Search by cofactor:
  • CoA
  • magnesium manganese (any)
  • magnesium manganese (both)
  • IntEnzAdvanced Search ExampleIntEnzBrowsing IntEnzBrowse the whole classification from the home pageIntEnzBrowsing via Enzyme entry
  • Browse upwards from an enzyme entry
  • IntEnzDownloading IntEnzIntEnzXMLIndividual enzymes/all of themASCII format/XChars-enhanced formatXSD availableQuery/format using XSLTenzyme.dat fileGenerated from IntEnz for SIBBioPAX level 2A standard exchange format for biological pathway dataBased in OWL (semantic web)IntEnz team and resourcesRafael Alcántara (Developer, EBI)Kristian Axelsen (Curator, SIB)Paula de Matos (Coordinator, EBI)Anne Morgat (Curator, SIB)Christoph Steinbeck (Team leader, EBI)http://www.ebi.ac.uk/intenzftp://ftp.ebi.ac.uk/pub/databases/intenzhttp://sourceforge.net/projects/intenzintenz-help@lists.sourceforge.netIntEnzExercises!http://www.ebi.ac.uk/intenz
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