SAMPLE. Wellness & Nutrition Report NAME GOES HERE

of 13

Please download to get full document.

View again

All materials on our website are shared by users. If you have any questions about copyright issues, please report us to resolve them. We are always happy to assist you.
PDF
13 pages
0 downs
3 views
Share
Description
Wellness & Nutrition Report NAME GOES HERE Your Genetic Control Panel John Smith Your gene expression / function approximates that of the general population. Your gene expression / function is moderately
Transcript
Wellness & Nutrition Report NAME GOES HERE Your Genetic Control Panel John Smith Your gene expression / function approximates that of the general population. Your gene expression / function is moderately impaired when compared to the general population. LOW MODERATE HIGH Your gene expression / function is significantly impaired when compared to the general population. FAT METABOLISM CARBOHYDRATE METABOLISM CELL DETOXIFICATION CAPABILITY SATIETY What is our genetically driven capacity to digest and break down Within the genes analyzed what is your ability to reduce free carbohydrates? How are these beneficial byproducts employed in oxygen radicals, and eliminate oxidative damage. overall health optimization? What is our genetically driven capacity to digest and break down fats? How are these beneficial byproducts employed in overall health optimization? How much food must we consume for our bodies to reach a state of fullness? LOW Genetically driven LOW Satiety hormone ability to reduce oxidative production as it relates to the LOW Fat metabolism LOW Carbohydrate toxins from our body genes analyzed approximates approximates that of the metabolism approximates approximates that of the that of the general general population that of the general population general population. population. MODERATE Decreased MODERATE Decreased MODERATE Fats moderately MODERATE Carbohydrates clearance of oxidative toxins production of satiety metabolized and their moderately metabolized and free oxygen radicals with hormone and as compared to byproducts moderately and their byproducts a greater genetically driven the general population must employed in health inadequately employed in chance of increasing the risk consume more quantities to optimization. health optimization. for the development of free - reach a state of fullness. radicals related illnesses. HIGH Fats poorly HIGH Carbohydrates poorly HIGH Further reduced metabolized and therefore, metabolized and therefore, HIGH Severely decreased production of satiety the beneficial byproducts the beneficial byproducts of clearance of oxidative toxins hormones, with a possible of fats in our diet are poorly carbohydrates in our diet are and free oxygen radicals with consequence of weight employed. scarcely employed. an even greater genetically gain when compared to driven chance of increasing the general population; free radical related illnesses. therefore at greater risk for development of obesity. LOW MODERATE HIGH LOW MODERATE HIGH LOW MODERATE HIGH LOW MODERATE HIGH FOOD INTAKE 0% 100% 0% 100% 0% 100% 0% 100% % of total caloric intake % of total caloric intake % of total caloric intake Less More FAT METABOLISM FABP2 The FABP2 gene plays a direct role in efficient fatty acid oxidation and utilization. Individuals with the Thr-54 genetic variant of FABP2 have reduced fatty acid oxidation, a higher incidence of obesity and elevated levels of insulin, glucose and cholesterol. For those who carry one or two copies of the Thr-54 variant of FABP2, a diet low in fats and cholesterol may be advisable. YOUR WBS SUMMARY: Genetic variants within this gene are associated with an elevated body mass index (BMI), total body and abdominal fat, and increased insulin resistance and fasting blood glucose. Therefore, your goals of achieving healthy insulin, glucose and cholesterol levels with lifestyle modifications alone may prove difficult. A combination of physical exercise and low fat diet may be the best way to achieve your personal health goals. PPARG PPARG plays an important role in controlling the production of fat cells (adipocytes) and normal lipid storage in various parts of the body. PPARG is produced in high amounts in brown or good fat tissues but not muscles. Accordingly, PPARG has a positive affect on normal fat production and storage increasing insulin sensitivity and healthy blood glucose levels. In the absence of genetic variants, the PPARG gene produces body mass index (BMIs), glucose metabolism and Type-2 diabetes risk typically found in the general population. On the other hand, individuals with the C;G or G;G variants appear to show slower fat metabolism than individuals in the general population. Research suggests that individuals with these variants may be more prone to becoming overweight regardless of the amount of food consumed in the diet. They may also struggle with maintaining healthy levels of insulin and glucose in the blood. YOUR WBS SUMMARY: How your body stores and utilizes fat is strongly influenced by the PPARG gene. The PPARG gene can also affect insulin levels and glucose metabolism. The effectiveness of PPARG (how much is made and/or how well it works) can in turn effect fitness, trainability, performance and overall health. PPARG contains genetic variants that can affect its production and function in the body. The C;G and G;G variants in PPARG are associated with reduce PPARG function. The consequence is the production of less good fat and reduced fat utilization, health and fitness. Whether you have one or two copies of a variant that decreases the affectiveness of the PPARG gene may also affect risk of not achieving your desired health goals. For example, Low Risk (C;C) suggests that your body s ability to burn and utilize fats approximates that of the general population. Moderate Risk (C;G) suggests that you don t burn and utilize the fats you consumed with the same effectiveness as those in the general population. Finally, High Risk Variant (G;G) suggests that your ability to burn and utilize fat may be all the more impaired. ADRB2 The ADRB2 gene is involved in the mobilization of fat for energy from fat cells (adipocytes) in response to hormones called catecholamines (epinephrine, norepinephrine and dopamine). This mobilization involves the break down of fat cells, the products of which are used as source of energy and other purposes. The end result of this process is the reduction in the number and size of fat containing cells. The A;A genetic variants in the ADRB2 gene is associated with a reduced function for this gene. The A;A variant may predispose an individual to excessive weight gain, as evident by an increased body mass index (BMI), and by an increase in the capacity of adipocytes to store a larger amount of fat FAT METABOLISM YOUR WBS SUMMARY: The genetic variants present in the ADRB2 gene play an important role in weight management. A Low-Risk variant (G;G) suggests that your ability to break down fats is similar to that found in the general population. The Moderate-Risk variant suggest that your efforts to loose weight may need to be augmented with a regimine of diet and exercise. A High-Risk variant suggest that a even greater effort may be needed to achieve your weight loss goals. Remember, that the presence or absence of a particularlar genetic variant is only one piece of a larger genomic puzzle. ADRB3 The ADRB3 gene is closely related to the ADRB2 gene in structure and function. The ADRB3 gene controls the normal process of fat breakdown within fat cells and its utilization as an energy source. Upon ingestion of fatty foods, the ADRB3 gene assists in fat storage. Individuals with the C;C variant (also known as the Arg64 variants) in the ADRB3 gene may have decreased physiological regulation and breakdown of fatty deposits within fat cells. Predisposing individuals to excessive weight gain, especially if they lead a sedentary lifestyle. The C;C variant is also associated with obesity-related hypertension. YOUR WBS SUMMARY: The ADRB3 similar to the ADRB2 gene, plays an important role in the use of fat from our bodies to generate sources of energy. A Low-Risk T;T variant of ADRB3 suggests that your ability to breakdown and utilize fats approximates that of the general population. The Moderate-Risk C;C variant suggests that the process of generating energy from our fat storage may be impaired and additional steps may be required to achieve your weight loss goals. A High-Risk C;C variant will likely require additional strategies such as individualized exercise and dietary plans, to achieve your healthy lifestyle goals. ADRB2-A The ADRB2-A gene plays an important role in fat metabolism, glucose tolerance, insulin resistance and obesity. In the general population, the ADRB2-A gene is associated with normal rates of these metabolic processes. It is believed that in individuals with the Glu27Glu or G;G variant fat metabolism is reduced leading to central obesity and in some instances, type-2 diabetes. People with the the Glu27Glu double variant may be more susceptible to weight gain and experience an increase in the size and number of the adipocytes (fat cells) in the body. YOUR WBS SUMMARY: Once fats are broken down and absorbed from the diet, the rate at which they are burned and how fast they are used for other physiological processes is controlled in part by genes like ADRB2-A. The Low Risk, Gln27Gln or C;C variant, is associated with fat metabolism similar to that found in the general population. The Moderate Risk variant (Gln27Glu or C;G) suggest that you may burn fat less efficiently than that found in the general population. The High Risk double variant, Glu27Glu (G:G), is thought to be associated with the lowest rate of fat metabolism and may result in even a lower rate fat breakdown and utilization rate resulting in a higher risk for impaired glucose tolerance, obesity and type-2 diabetes. In consultation with your nutritionist or trainer, you may want to develop a diet and training regime that helps you metabolize fat more efficiently. CARBOHYDRATE METABOLISM ADRB2-A The ADRB2-A gene plays an important role in fat metabolism, glucose tolerance, insulin resistance and obesity. In the general population, the ADRB2-A gene is associated with nornal rates of these metabolic processes. It is believed that in individuals with the Glu27Glu or G;G variant, fat metabolism is reduced leading to central obesity and in some instances, type-2 diabetes. People with the the Glu27Glu double variant may be more susceptible to weight gain and experience an increase in the size and number of the adipocytes (fat cells) in the body). The ADRB2-A (rs ) SNP is frequently used as an indicator of impaired carbohydrate metabolism. With ongoing research it has been noted that its role seems to be inclusive of areas related to fat metabolism as well. There are evolving studies on the role of ADRB2-A (rs ) and its association in other health related areas as well. YOUR WBS SUMMARY: Once fats are broken down and absorbed from the diet, the rate at which they are burn and how fast they are use for other physiological processes is controlled in part by genes like ADRB2-A. The Low Risk, Gln27Gln or C;C variant, is associated with fat metabolism similar to that found in the general population. The Moderate risk variant (Gln27Glu or C;G) suggest that you may burn fat less efficiently than that found in the general population. The High Risk double variant, Glu27Glu (G:G), is thought to be associated with the lowest rate of fat metabolism and may result in even a lower rate fat breakdown and utilization rate resulting in a higher risk for impaired glucose tolerance, obesity and type-2 diabetes. In consultation with your nutritionist or trainer, you may want to develop a diet and training regime that helps you metabolize fat more efficiently. SATIETY LEPR (rs ) FTO (rs ) Leptin, a protein synthesized in the body s fat cells (adipocytes), has been called The FTO (Fat mass and obesity associate gene) gene is one of the most important the Satiety Hormone. It circulates in the bloodstream regulating energy levels genes controlling energy balance, fat cell growth and fat oxidation. As a in the body and controlling weight through inhibiting hunger. When leptin levels consequence, genetic variants in the FTO gene show strong associations with high are above a specific threshold, it causes the brain to sense that there is enough BMI, obesity Type-2 diabetes and cardiovascular disease. Relative to the general energy for the demands on the body. This leads to an efficient energy metabolism, population, the single (A) variant is a risk factor for obesity and Type-2 diabetes. causing the individual to consume an adequate amount of food as well as exercise The double varient in FTO (A;A) is an even stronger risk factor for obesity and at a normal pace. If the levels of this hormone are below a normal threshold, the Type-2 diabetes relative to the general population. The FTO A variant is only one body senses that it needs more energy, causing the person to feel hungrier, eat of several that are associated with obesity and Type-2 diabetes. Environmental and excessive amounts of food, and exercise at a lower intensity in order to save the lifestyle factors can be modifiers of the A:A variant. needed energy. In order to achieve this regulation, leptin must bind to its receptor (LEPR) in the brain. Genetics variants in the LEPR gene like Q223R (rs ) do YOUR WBS SUMMARY: Like PPARG and the ADRB2 genes, FTO is a regulator of not transmit the leptin satiety signal efficiently. This leads to a sensation of hunger, energy expenditure, BMI, and fat oxidation. Low Risk, (no variant) mean that your compulsive eating and weight gain. risk for obesity, Type-2 diabetes and cardiovascular disease closely approximates that of the general population. Moderate risk means that you may be at risks for YOUR WBS SUMMARY: Leptin is one of our body s regulatory hormones. The these conditions. High Risk means your double A variant puts you at higher risk of more Leptin production by our bodies, the less we will feel hungry. The leptin for obesity, Type-2 diabetes and cardiovascular disease than the single A variant. signal is transmitted to the satiety center of the brain by the leptin receptor (LEPR). Both Moderate and High Risk conditions suggest that you may need to make a Low Risk means that your ability to sense the leptin hormone in your body closely special effort to control your weight with a low fat diet and physical exercise. approximates that of the regular population. Moderate Risk can be associated with the presence of a single variant such as Q223R which may create the unnecessary sensation of hunger and inappropriate portion control. A High Risk variant such as double variant of Q223R may further decrease leptin signaling resulting in difficulty achieving satiety, compulsive eating, obesity and problems like type-2 diabetes and heart disease. Remember that genetics is only one piece of the puzzle. In many instances, diet and exercise, together with knowledge can help you define the right path to your health and wellness journey. CELL DETOXIFICATION CAPABILITY GENES ANALYZED: SOD2-MNSOD (rs4880) GPX1 (rs ) NQO1 (rs ) SOD3 (rs ) UCP1 (rs ) TNF-A (rs ) SOD2-MNSOD (rs4880): REMOVAL OF FREE RADICALS AND ANTI-OXIDATIVE ABILITY Oxidative stress in the body has been defined as the cellular imbalance of pro-oxidants versus antioxidants. Antioxidants are desirable for your body while pro-oxidants are undesirable because they can overburden the systems involved in removing damaging reactive oxygen species (ROS) from the body. Examples of antioxidants include compounds like vitamin C and E, the short chain fatty acid, alpha lipoic acid and enzymes like SOD2-MNSOD. The common feature of all antioxidants is the removal of potentially damaging oxidizing agents that can damage the contents of a living cell. The A16V (C;C) genetic variant in the SOD2-MNSOD gene is associated with reduced enzyme activity and thus increased oxidative stress, suggesting and increased risk for oxidative-stress related diseases. YOUR WBS SUMMARY: The SOD2-MNSOD gene is involved in the production of antioxidants that remove oxidative toxins from the bloodstream. The Low Risk genetic variant T;T is associated with SOD2-MNSOD activity that approximates that found in the general population. The Moderate Risk variant C;T and the double variant (C;C) have enzyme activity 33% lower than the more common T;T variant. Individuals with the C;T or C;C variants may want to consider increasing antioxidant foods and beverages in their diets. GPX1 (rs ) GPX1 belongs to the family of glutathione peroxidases genes that plays a important role in the detoxification of hydrogen peroxide, which is detrimental to your body. This gene is found in many tissues, where it protects cells from oxidative stress via the detoxification of hydrogen peroxide. Prevention of hydrogen peroxide buildup or exposure in different tissues can reduce disorders related to the aging process. The C;T and T;T genetic variants within this gene are believed to have a lower capacity to render the body free of the damages caused by hydrogen peroxide. YOUR WBS SUMMARY: The GPX1 gene, in combination with SOD-MNSOD, assists in ridding the body of oxidative toxins and thus reduces oxidative stress. Low Risk would mean that, production expression of GPX1 and its these beneficial antioxidants approximates that of the general population. The Moderate Risk variant C;T is less effective than in reducing oxidative stress. The High Risk T:T variant can be even less effective than a Moderate Risk variant in terms of reducing oxidative stress. Having genetic variants within both GPX-1 could increase your oxidative toxins exposure. NQO1 (rs ) These genes work in combination with GPX1 and with SOD2-MNSOD to additionally protect the body from unwanted oxidative stress/free radicals. The specific free radicals removed with the proper expression of this gene are known as quinonoid compounds. The expression of this gene plays a role in the removal of these compounds thus improving overall detoxification. YOUR WBS SUMMARY: This gene in combination with SOD-MNSOD and GPX-1 assists in ridding the body from oxidative toxins. Low Risk would mean that, production of these beneficial antioxidants approximates that of the general population. As you are presented with the spectrum of possible oxidative damage, understand that a High Risk T;T variant poses an even greater stressor than the Moderate Risk C;T variant. Having genetic variants within NQO-1, GPX-1 and SOD2-MNSOD would increase your oxidative toxins exposure, and possibly decreased clearance of such. CELL DETOXIFICATION CAPABILITY SOD3 (rs ) brain and white fat tissue. Several studies have cardiovascular disease and hypertension, collectively The SOD3 gene encodes a member of antioxidant associated genetic variants in UPC genes to obesity known as metabolic syndrome. In its early stages, enzymes (good enzymes) that assist in the break down and/or type-2 diabetes. Another function of UCP2 is insulin-resistance and related mild glucose intolerance of two superoxide radicals into hydrogen peroxide and to regulate the production of reactive oxygen species may be compensated for by increased insulin oxygen commonly found in injured skin. The product (ROS) and transport of certain metabolites across secretion. However, if insulin secretion is impaired, of this gene is thought to protect the brain, lungs, the mitochondrial membrane. In absence of genetic insulin resistance prevails producing a variety of and other tissues including skin from oxidative stress. variants, UCP2 protects the body from oxidative stress. pathological conditions, including trauma, infection, Owing to the high levels of oxidative stress present The less oxygen available due to genetic variants and cancer. It is now known that fat, especially visceral in injured skin, genetic variants within the gene can within the gene, the higher the increase in free radicals fat, is an endocrine organ producing a number of cause a decreased wound healing response and repair and hydrogen peroxide. Vigorous physical exercise substances that can play a role in the development of of skin injury. and lifestyles factors can also cause oxidative stress. insulin resistance. One of these substances is tumor Fort
Related Search
We Need Your Support
Thank you for visiting our website and your interest in our free products and services. We are nonprofit website to share and download documents. To the running of this website, we need your help to support us.

Thanks to everyone for your continued support.

No, Thanks