X Inactivation Hypothesis

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X Inactivation Hypothesis . - proposed by Mary Lyons - British geneticist. Barr Bodies. When one of the X chromosomes inactivates, it condenses into a black spot outside of the nucleus This inactivation occurs in a random pattern. XY – no barr bodies XXY – 1 barr body. XX – 1 barr body
Transcript
X Inactivation Hypothesis - proposed by Mary Lyons - British geneticistBarr Bodies
  • When one of the X chromosomes inactivates, it condenses into a black spot outside of the nucleus
  • This inactivation occurs in a random pattern
  • XY – no barr bodiesXXY – 1 barr bodyXX – 1 barr bodyXXX – 2 barr bodiesHow many Barr Bodies?Practical Example
  • Calico Cats
  • They carry 2 different alleles for coat color
  • Random X inactivation during embryonic development causes the patchwork colored coat in some female cats
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